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Other documented findings include a tendency toward IGF-1 receptor desensitization with prolonged, continuous exposure, transient fluid retention in early study phases, and at supraphysiological exposure levels examined in some research acromegaly-like tissue changes

310, 800807.10.1124/jpet.104.065300 182 MurakamiK.MiyakeY.SasakiS.TanakaK.FukushimaW.KiyoharaC.TsuboiY.YamadaT.OedaT.MikiT.KawamuraN.SakaeN.FukuyamaH.HirotaY.NagaiM

The trade-off is two injections per week (different sites, same day or split days) and two reconstitutions

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